amanyathelo aneenkcukacha malunga nendlela yokusebenzisa ii-embolic microspheres

Ii-Embolic Microspheres zii-hydrogel microspheres ezinokucinezelwa ezinemilo eqhelekileyo, umphezulu ogudileyo, kunye nobukhulu obulinganisiweyo, ezenziwe ngenxa yokuguqulwa kweekhemikhali kwizinto ze-polyvinyl alcohol (PVA). Ii-Embolic Microspheres zenziwe yi-macromer ethathwe kwi-polyvinyl alcohol (PVA), kwaye ziyakwazi ukufudumala emanzini, azikwazi ukuxutywa, kwaye zifumaneka ngobukhulu obahlukeneyo. Isisombululo sokugcina sisisombululo se-sodium chloride esingu-0.9%. Umxholo wamanzi we-microsphere e-polymerized ngokupheleleyo yi-91% ~ 94%. Ii-Microspheres zinokunyamezela ukucinezelwa kwe-30%.

Ii-Embolic Microspheres zenzelwe ukusetyenziselwa ukuqinisa imithambo yegazi emithanjeni (ii-AVM) kunye nee-hypervascular tumors, kuquka nee-uterine fibroids. Ngokuthintela ukuhanjiswa kwegazi kwindawo ekujoliswe kuyo, ithumba okanye i-malformation ayifumani izondlo kwaye iyancipha ngobukhulu.

Kule nqaku, siza kukubonisa amanyathelo aneenkcukacha malunga nendlela yokusebenzisa ii-Embolic Microspheres.

Ukulungiswa kweempahla

Kuyimfuneko ukulungiselela isirinji eyi-1 20ml, iisirinji ezi-2 10ml, iisirinji ezi-3 1ml okanye 2ml, izikere zotyando ezintathu, indebe ecocekileyo, amayeza e-chemotherapy, ii-embolic microspheres, i-contrast media, kunye namanzi okujova.

Inyathelo 1: Lungiselela amayeza e-chemotherapy

Sebenzisa isikere sotyando ukuvula ibhotile yamayeza e-chemotherapy uze ugalele amayeza e-chemotherapy kwikomityi engenazintsholongwane.
Uhlobo kunye nomthamo wamayeza e-chemotherapy kuxhomekeke kwiimfuno zonyango.

Sebenzisa amanzi ukujova ukuze unyibilikise amayeza e-chemotherapy, kwaye uxinaniso olucetyiswayo lungaphezulu kwe-20mg/ml.

AEmva kokuba iyeza le-chemotherapeutic linyibilikisiwe ngokupheleleyo, isisombululo seyeza le-chemotherapeutic sikhutshwe ngesirinji ye-10ml.

Inyathelo lesi-2: Ukukhupha ii-embolic microspheres ezithwala iziyobisi

Ii-microspheres ezifakwe kwi-embolism zashukunyiswa ngokupheleleyo, zafakwa kwinaliti yesirinji ukuze kulinganiswe uxinzelelo olusebhotileni,kwaye ukhuphe isisombululo kunye nee-microspheres kwibhotile ye-cillin ngesirinji ye-20ml.

Yiyeke i-syringe ime imizuzu emi-2-3, kwaye emva kokuba ii-microspheres zizinzile, i-supernatant ityhalelwa ngaphandle kwesisombululo.

Inyathelo lesi-3: Faka amayeza eChemotherapeutic kwi-Embolic Microspheres

Sebenzisa iindlela ezintathu ze-stopcock ukudibanisa isirinji ne-embolic microsphere kunye nesirinji neyeza le-chemotherapy, qaphela uqhagamshelo ngokuqinileyo kunye necala lokuhamba kwalo.
Tyhala isirinji yeyeza le-chemotherapy ngesandla esinye, uze utsale isirinji ene-embolic microspheres ngesinye isandla. Ekugqibeleni, iyeza le-chemotherapy kunye ne-microsphere zidityaniswe kwisirinji ye-20ml, ushukumise kakuhle isirinji, uze uyishiye imizuzu engama-30, uyishukumise rhoqo emva kwemizuzu emi-5 ngexesha lesehlo.

Inyathelo lesi-4: Yongeza imidiya yokwahlulahlula

Emva kokuba ii-microspheres zizaliswe ngamayeza e-chemotherapy imizuzu engama-30, umthamo wesisombululo ubalwe.
Yongeza umthamo we-contrast agent ophindwe ka-1-1.2 nge-stopcock eneendlela ezintathu, shukumisa kakuhle uze uyiyeke ime imizuzu emi-5.

Inyathelo lesi-5: IiMicrospheres zisetyenziswa kwinkqubo ye-TACE

Ngesi stopcock esineendlela ezintathu, faka malunga ne-1ml yeemicrospheres kwisirinji ye-1ml.

Ii-microspheres zifakwe kwi-microcatheter nge-pulsed injection.

Izikhokelo zengqalelo:

Nceda uqinisekise ukusebenza kwe-aseptic.
Qinisekisa ukuba amayeza e-chemotherapy anyibilikiswe ngokupheleleyo ngaphambi kokuba uwafake kwi-intanethi.
Uxinzelelo lwamayeza e-chemotherapy luya kuchaphazela isiphumo somthwalo wamayeza, okukhona uxinzelelo luphezulu, kokukhona izinga lokufunxwa likhawuleza, uxinzelelo olucetyiswayo lomthwalo wamayeza alukho ngaphantsi kwe-20mg/ml.
Kuphela ngamanzi angenazintsholongwane okujova okanye i-5% ye-glucose injection ekufuneka isetyenziswe ukunyibilikisa amayeza e-chemotherapy.
Izinga lokunyibilika kwe-doxorubicin emanzini angenazintsholongwane xa kujovwa lalikhawuleza kancinci kune-5% ye-glucose injection.
Inaliti ye-5% yeglucose inyibilikisa i-pirarubicin ngokukhawuleza kancinci kunamanzi angenazintsholongwane okujova.
Ukusetyenziswa kwe-ioformol 350 njenge-contrast medium kwakuluncedo ngakumbi ekumisweni kwee-microspheres.
Xa ifakwa kwi-tumor nge-microcatheter, kusetyenziswa i-pulse injection, enceda ngakumbi ekumisweni kwe-microsphere.