Amanyathelo aneenkcukacha malunga nendlela yokusebenzisa i-embolic microspheres

I-Embolic Microspheres i-compressible hydrogel microspheres enemilo eqhelekileyo, indawo egudileyo, kunye nobukhulu obulinganisiweyo, obunjwe ngenxa yokuguqulwa kweekhemikhali kwizinto ze-polyvinyl alcohol (PVA). I-Embolic Microspheres iqulethe i-macromer evela kwi-polyvinyl alcohol (PVA), kwaye i-hydrophilic, i-non-resorbable, kwaye ifumaneka kuluhlu lweesayizi. Isisombululo sokugcina yi-0.9% yesisombululo se-sodium chloride. Isiqulatho samanzi se-polymerized microsphere ngokupheleleyo yi-91% ~ 94%. I-Microspheres inokunyamezela ukunyanzeliswa kwe-30%.

Ii-Microspheres ze-Embolic zenzelwe ukusetyenziselwa ukunyanzeliswa kwe-arteriovenous malformations (AVMs) kunye ne-hypervascular tumors, kuquka i-uterine fibroids. Ngokuthintela ukunikezelwa kwegazi kwindawo ekujoliswe kuyo, i-tumor okanye i-malformation ilambile izondlo kwaye iyancipha ngobukhulu.

Kweli nqaku, siza kukubonisa amanyathelo aneenkcukacha malunga nendlela yokusebenzisa i-Embolic Microspheres.

Ukulungiswa kwempahla

Kuyimfuneko ukulungiselela 1 20ml isirinji, 2 10ml iisirinji, 3 1ml okanye 2ml iisirinji, iindlela ezintathu, isikere sotyando, indebe oyinyumba, amayeza echemotherapy, microspheres embolic, imidiya eyahlukileyo, kunye namanzi enaliti.

Inyathelo 1: Lungiselela amayeza echemotherapy

Sebenzisa isikere sotyando ukukhulula ibhotile yeyeza le-chemotherapeutic kwaye ugalele iyeza le-chemotherapeutic kwikomityi engenazintsholongwane.
Uhlobo kunye nomthamo weziyobisi ze-chemotherapeutic zixhomekeke kwiimfuno zeklinikhi.

Sebenzisa amanzi ukujova ukuze uchithe iziyobisi ze-chemotherapy, kwaye ukugxininiswa okucetyiswayo kungaphezulu kwe-20mg / ml.

Aemva kokuba iyeza le-chemotherapeutic lichithwe ngokupheleleyo, isisombululo sechiza le-chemotherapeutic sakhutshwa ngesirinji eyi-10ml.

Inyathelo lesi-2: Ukukhutshwa kwee-embolic microspheres ezithwele iziyobisi

I-microspheres embolized yashukunyiswa ngokupheleleyo, yafakwa kwinaliti yesirinji ukulinganisa uxinzelelo kwibhotile,kwaye ukhuphe isisombululo kunye ne-microspheres kwibhotile ye-cillin nge-syringe ye-20ml.

Vumela i-syringe ime imizuzu engama-2-3, kwaye emva kokuba i-microspheres ihlale, i-supernatant ikhutshwe ngaphandle kwesisombululo.

Inyathelo lesi-3: Layisha amachiza eChemotherapeutic kwi-Embolic Microspheres

Sebenzisa iindlela ezi-3 ze-stopcock ukudibanisa i-syringe kunye ne-embolic microsphere kunye nesirinji kunye neyeza le-chemotherapy, qaphela uxhulumaniso ngokuqinileyo kunye nolwalathiso lokuhamba.
Tyhila isirinji yeyeza lechemotherapy ngesandla esinye, kwaye utsale isirinji eneembolic microspheres ngesinye isandla. Ekugqibeleni, iyeza le-chemotherapy kunye ne-microsphere zixutywe kwi-syringe ye-20ml, xubha i-syringe kakuhle, kwaye uyishiye imizuzu engama-30, uyigubungele yonke imizuzu emi-5 ngeli xesha.

Inyathelo 4: Yongeza imidiya yokuchasana

Emva kokuba i-microspheres ilayishwe ngamachiza e-chemotherapeutic imizuzu engama-30, umthamo wesisombululo ubalwa.
Yongeza amaxesha angama-1-1.2 umthamo we-agent echaseneyo kwi-stopcock yeendlela ezintathu, xubha kakuhle kwaye uvumele ume imizuzu emi-5.

Inyathelo lesi-5: Kusetyenziswa ii-Microspheres kwinkqubo ye-TACE

Ngeendlela ezintathu istopcock, tofa malunga ne-1ml yemicrospheres kwisirinji eyi-1ml.

I-microspheres yafakwa kwi-microcatheter ngenaliti ye-pulsed.

Izikhokelo:

Nceda uqinisekise ukusebenza kwe-aseptic.
Qinisekisa ukuba amachiza ekhemotherapeutic anyibilika ngokupheleleyo phambi kokulayisha amachiza.
Ukuxinwa kweziyobisi ze-chemotherapy kuya kuchaphazela umphumo wokulayishwa kweziyobisi, ukuphakama koxinzelelo, ngokukhawuleza izinga le-adsorption, i-concentration yokulayisha iziyobisi ekhuthazwayo ayikho ngaphantsi kwe-20mg / ml.
Kuphela ngamanzi angcolileyo okutofwa okanye i-5% yesitofu seswekile kufuneka asetyenziswe ukunyibilikisa amayeza echemotherapy.
Izinga lokunyibilika kwe-doxorubicin emanzini angenazintsholongwane kwinaliti ibikhawuleza kancinci kune-5% yesitofu seswekile.
I-5% yesitofu seswekileyi inyibilikisa ipirarubicin ngokukhawuleza kancinci kunamanzi angenazintsholongwane okutofwa.
Ukusetyenziswa kwe-ioformol 350 njengesixhobo sokuthelekisa kube luncedo ngakumbi ekunqunyanyisweni kwee-microspheres.
Xa utofwe kwi-tumor ngokusebenzisa i-microcatheter, kusetyenziswa inaliti ye-pulse, eyenza ngakumbi ukumiswa kwe-microsphere.